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The toxicity of corticosteroids has led to efforts to identify alternative or adjunctive treatments that reduce exposure to these drugs in patients with giant cell arteritis or polymyalgia rheumatica, according to the report published online Aug. 18 in The Journal of the American Medical Association. Patients must remain asymptomatic for up to several weeks before receiving a corticosteroid therapy, or for up to several months if they are receiving a corticosteroid regimen during a disease-specific inflammatory response. The authors also suggest that doctors use more objective tests to distinguish acute from chronic inflammation to evaluate patients. "These findings can guide the design of new diagnostic tests and therapy aimed at decreasing exposure to drugs and other agents in patients who suffer from giant cell arteritis," Dr. Edward D. Kremenchuk, a professor of medicine at Vanderbilt University School of Medicine and director of the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and senior author of the report, said in a statement. "These findings have particular relevance because drug exposure is associated with adverse events and adverse drug reactions and can be important sources of patients' complaints, particularly in these patients who may not require invasive angiograms." The report was co-authored by Drs. Michael W. Jäckberg and John P. Hines, both of the University of Florida College of Medicine, and Dr. Richard E. Wohlers, of Yale University School of Medicine, and Dr. George I. Himmelstein, of Yale School of Medicine, in collaboration with Dr. Edward M. J. Sisodia, of the Mayo Clinic. Follow Rachael Rettner @RachaelRettner. Follow Live Science @livescience, Facebook & Google+. Original article on Live Science. Related Article: